Investigation of Candidemia Diagnosis by PCR Method in Febrile Neutropenic Patients with Hematological Malignancies

Objective: Candidiasis" is the predominant fungal infection that occurs invasively and opportunistically in individuals with compromised immune systems. Febrile neutropenia patients receiving cytotoxic chemotherapy due to malignancy, especially acute leukemia stem cell transplantation are at greater risk among many others. In this study, it was aimed search for Candida DNA make an early diagnosis by using PCR method Materials & Method: This prospective study conducted Pediatric Hematology Transplantation Clinic of Akdeniz University. The enrolled 78 malignancies candidiasis who were experiencing febrile neutropenia. neutropenic episodes identified prospectively monitoring daily leukocyte counts fever symptoms patients. Results: grown blood cultures seven (9%) included study. All breeding Candidas C.albicans. underlying primary 6 (85.7%) reproduction hematological while one (12.5%) solid malignancy (Neuroblastoma). detected 9% Neutropenic C.albicans all DNA. Conclusion: As a result, conclusion drawn cases where candidemia suspected, particularly immuno-compromised high mortality, rapid accurate sensitivity specificity necessary.